PROCEDURE FOR RECEIPT, STORAGE , HANDLING OF LABORATORY REAGENTS AND GLASSWARE

2.0 SCOPE:

This procedure is applicable to laboratory reagents used at Quality Control Department

3.0 REFERENCES:

In House

4.0 RESPONSIBILITY

4.1 Analyst

4.1.1 To provide information about chemical / reagent to be procured and follow the procedure as per laid down procedure.

4.1.2 To maintain the document as per laid down procedure.

4.2 Section Head or Designee

4.2.1 To initiate the indent for procurement of chemical/reagent required for laboratory

4.2.2 To give training to all concerned persons to follow the SOP.

4.3 Quality Control Head or Dcsignee

4.3.1 To take necessary action to get procure the required chemical/ reagent for laboratory.

4.3.2 Training to the concern before implementation of SOP.

4.4 Quality Assurance

4.4.1 To ensure that the handling of laboratory reagents as per laid down procedure

5.0 PROCEDURE

5.1 Reagents Procurement Procedure

5.1.1 Reagents/chemical shall be procured by the designated QC person.

5.1.2 Analyst shall inform to designated person whenever any requirement of reagent/chemicals and mentioned the required details in reagent requirement register. Designated person shall inform to the supplier about required quantity.

5.2 Reagents Receiving Procedure:

5.2.1 On the receipt of Reagent /Chemicals fill the receipt qty. and necessary details in Annexure and maintain the stock.

5.2.2 On the receipt of Glass wares fill the receipt qty. and necessary details in Annexure-5 and maintain stock.

5.2.3 Reagents shall be received by designated person and verify against the reagent/chemical requisition book.

5.2.4 Designated person shall observe the physical condition of the container / bottles / packs.

5.2.5 If any damaged container or improper storage and quantity mismatch is observed, designated person shall inform to Head – QC or designee and return the material to supplier for the replacement.

5.2.6 After receiving the reagent, designated person shall paste the label as shown in Annexure-1 on the container having details like, Date of Receipt/signature, first time opened on/sign and exp. date.

5.2.7 Designated person shall arrange MSDS and certificate of analysis, if required

5.3 Storage of Chemicals/ Reagents:

5.3.1 Store the chemicals / reagents in a designated reagent/chemical storage room controlled at not more than 25°C.

5.3.2 Store the chemicals / reagents as per the manufacturer’s instructions on the container considering safety precautions.

5.3.3 Store the opened acid bottles at well-ventilated area.

5.3.4 In case of general reagent, where specific storage condition is not required, shall be stored at ambient temperature.

5.3.5 In case where storage condition of reagent is mentioned as store below J 5°C, shall be stored in refrigerator.

5.3.6 In case where storage condition of reagent is mentioned as store below 0°C, shall be stored in deep freeze.

5.4 General Usage Procedure:

5.4.1 Analyst shall take out the required reagent for usage from chemical store in case of existing reagent exhausted. Analyst shall fill the remaining details like, Date of opening, signature and Exp. date on the label pasted at the time of receipt. If label is not affix, then analyst shall not use such reagent.

5.4.2 Analyst shall codify the reagents according to Annexure 7 and arrange the reagents alphabetical manner in cupboard of working table of respective location.

5.4.3 Reagents coding shall be done at the time of receipt ofreagent, designated person shall give the specific code to the reagent (like AS for Solid Chemicals, AL for liquid chemicals, and AI for Indicators) and maintain the list of reagents with code.

Code: first alphabet of reagent with serial number

E.g. 3-Aminopyridine Code: AS/01 Aluminum Chloride GR Code: AS/02 Barium chloride 2-hydrate GR Code: BS/0 I Zinc Acetate extra Pure Code: ZS/0 I

5.4.4 After opening of reagent bottle, if any abnormal observation found in physical appearance of reagent, analyst shall infom1 to Head QC or designee and then discard it and take the new chemical / reagent bottle.

5.4.5 After usage of reagent, bottle shall be kept back in cupboard rack of working table in laboratory.

5.4.6 Use before date for solid reagents, solvents and acids shall be three years from the date of opening, where expiry date is not provided by manufacturer.

5.4.7 In case where manufacturer provides expiry date, follow the mentioned expiry date on the bottle.

5.5 Precautions

5.5.1 Always assure the intactness of reagent bottle in storage area and also before use for analytical purpose.

5.5.2 Always use safety equipment’s (like hand gloves, mask, goggle etc) where as required.

5.5.3 Always refer MSDS and handling precautions while handling poisonous and toxic chemicals/reagents.

5.5.4 Do not use any reagents after expiry date as mentioned on the label of the bottle/container.

5.6 Consumption of Acetic Anhydride

5.6.1 The usage of Acetic Anhydride is controlled.

5.6.2 Consumption record of Acetic Anhydride is maintained as annexure.

5.6.3 Acetic Anhydride shall be kept under control

5.7 Destruction Procedure:

5.7.1 If the reagents are present after the date of “use before”, remaining quantity shall be destroyed as per the following procedure.

Destruction of solid reagent

5.7.2 Take about IO liters beaker and pour about 5 liters of raw water into the beaker.

5.7.3 Add the solid chemical slowly into the water with stirring by suitable glass rod, mix it to dissolve completely and drain the slurry or send to ETP inlet.

Destruction of Acids

5.7.4 Take plenty of water in a container and add the acid slowly with stirring through sides of the beaker

5.7.5 If temperature is observed in the container, add more water, cool it and drain it.

6.0 DEFINITION :

NA

7.0 ABBREVIATIONS

MSDS: Material Safety Data Sheet.

ETP: Effluent Treatment Plant.